Results
| PMID | 25197000 |
| Gene Name | MUC16 |
| Condition | Endometriosis |
| Association |
Associated |
| Population size | 95 |
| Population details | 95 (59 patients with endometriosis, 36 patients with epithelial ovarian carcinoma (EOC)) |
| Sex | Female |
| Other associated phenotypes |
Epithelial ovarian carcinoma |
|
Int J Cancer. 2015 Apr 15;136(8):1985-90. doi: 10.1002/ijc.29185. Epub 2014 Sep Sasaki, Aya| Akita, Kaoru| Ito, Fumitake| Mori, Taisuke| Kitawaki, Jo| Nakada, Hiroshi Department of Molecular Biosciences, Faculty of Life Sciences, Kyoto Sangyo University, Kyoto, Japan; Department of Obstetrics and Gynecology, Kyoto Prefectural University of Medicine, Kyoto, Japan. The epithelial ovarian carcinoma (EOC) is an aggressive malignant tumor, and is currently the leading cause of gynecologic cancer death. CA125 is the most commonly used serum marker for EOC, but shows a high-false-positive rate for several benign diseases such as endometriosis. The purpose of our study is therefore to identify a useful biochemical tool for detecting qualitative differences between CA125 from patients with endometriosis and EOC, and to facilitate differential diagnosis of these diseases. In our study, using two different CA125-binding molecules, i.e., recombinant mesothelin and an anti-CA125 monoclonal antibody, a novel sandwich ELISA for determining the serum levels of CA125 with mesothelin-binding ability (CA125(meso) ) was developed, and tested for patients with endometriosis (n = 59) and EOC (n = 36). We found that both the serum CA125(meso) level and the ratio of the serum CA125(meso) to CA125 levels (CA125(meso) /CA125) were significantly higher in patients with EOC than in patients with endometriosis (p < 0.00005 and p < 0.000001, respectively). Furthermore, receiver operating characteristic analysis showed that the CA125(meso) assay was superior to the conventional antibody-based CA125 assay in discriminating endometriosis from EOC. Thus, mesothelin-binding ability may be a useful indicator for qualitatively evaluating CA125 in patients with endometriosis and EOC. Mesh Terms: Adult| Aged| Aged, 80 and over| Biomarkers, Tumor/blood/metabolism| CA-125 Antigen/*blood/*metabolism| Endometriosis/*blood/*metabolism| Female| GPI-Linked Proteins/*metabolism| Humans| Middle Aged| Mucins/metabolism| Neoplasms, Glandular and E |
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